Fine Needle Aspiration of Thyroid Nodules

In order to understand Fine Needle Aspiration Thyroid of Nodules you must first learn about thyroid nodules..

Thyroid Nodules

Basic facts:

Simply put, thyroid nodules are lumps which commonly arise within an otherwise normal thyroid gland. Often these abnormal growths of thyroid tissue are located at the edge of the thyroid gland so they can be felt as a lump in the throat. When they are large or when they occur in very thin individuals, they can even sometimes be seen as a lump in the front of the neck.

The following is a list of facts regarding thyroid nodules:

  • One in 12 to 15 young women has a thyroid nodule
  • One in 40 young men has a thyroid nodule
  • More than 95 percent of all thyroid nodules are benign (non-cancerous growths)
  • Some are actually cysts which are filled with fluid rather than thyroid tissue
  • Most people will develop a thyroid nodule by the time they are 50 years old
  • The incidence of thyroid nodules increases with age
  • 50% of 50 year olds will have at least one thyroid nodule
  • 60% of 60 year olds will have at least one thyroid nodule
  • 70% of 70 year olds will have at least one thyroid nodule

Three questions that should be answered about all thyroid nodules:

Three questions that should be answered about all thyroid nodules:

  • Is the nodule one of the few that are cancerous?
  • Is the nodule causing trouble by pressing on other structures in the neck?
  • Is the nodule making too much thyroid hormone?

After an appropriate work-up, most thyroid nodules will yield an answer of NO to all of the above questions. In this most common situation, there is a small to moderate sized nodule which is simply an overgrowth of “normal” thyroid tissue, or even a sign that there is too little hormone being produced. Patients with a diffusely enlarged thyroid (called a goiter) will present with what is perceived at first to be a nodule, but later found to be only one of many benign enlarged growths within the thyroid (a goiter). Usually a fine needle aspiration biopsy (FNA) will tell if the nodule is cancerous or benign. This one test can get right to the bottom of the issue. Often an Ultrasound examination is necessary to determine the characteristics of a thyroid nodule.

Symptoms of thyroid nodules

Most thyroid nodules cause no symptoms at all. They are usually found by patients who feel a lump in their throat or see it in the mirror. Occasionally, a family member or friend will notice a strange lump in the neck of someone with a thyroid nodule. Another common way in which thyroid nodules are found is during a routine examination by a physician.

Occasionally, nodules may cause pain, and even rarer still are those patients who complain of difficulty swallowing when a nodule is large enough and positioned in such a way that it impedes the normal passage of food through the esophagus (which lies behind the trachea and thyroid).

Occasionally a thyroid nodule is found because the patient is undergoing a CT scan, MRI scan, or ultrasound scan of the neck for some other reason (parathyroid disease, carotid artery disease, cervical spine pain, etc). Thyroid nodules found this way (by accident) are cancerous far less than 1% of the time. If this is you, then please stop worrying.

I have a nodule! What do I do?

First of all, remember that the vast majority of thyroid nodules are benign. Next, the nodule should be evaluated by a physician who is comfortable with this problem. Endocrinologists and Endocrine Surgeons deal with these problems on a regular basis, but many family practice physicians, general internists, and general surgeons are also adept at addressing thyroid nodules. This is covered in more detail on our nodule exam/biopsy page.

One of the first things that a physician will do will be to ask a number of important questions regarding your health and potential thyroid problems. These questions include whether or not you have been exposed to nuclear radiation or received radiation treatments as a child or teenager.

What about radiation exposure?

Ionizing radiation has been known for a number of years to be associated with a SMALL increased risk of developing thyroid cancer. The risk is very small and the amount of radiation exposure is usually quite high. There is typically a delay of 20 years or more between radiation exposure and the development of thyroid cancer.

Radiation was used occasionally between the 1920s and 1950s to treat certain neck infections such as recurrent tonsillitis as well as certain skin conditions such as severe acne.

In July, 1997 the U.S. government announced the results of a scientific study to determine if the nuclear weapons testing in the Southeast U.S. from 1945 through the 1970s would have an effect on the development of thyroid cancer in Americans. This epidemiological study determined that these nuclear tests would likely increase the amount of thyroid cancers seen in Americans over the next several decades. The risks are substantially greater for those patients living nearby the test sites for many years. If there is any good news to this report, it is that these cancers will typically be of the well differentiated type which have an excellent prognosis…the vast majority of these can be cured. There is NO evidence that children are at increased risk of developing thyroid cancer, the small increase risk appears to be limited to those that were directly exposed in the past. Despite these increased risks, thyroid cancer is still relatively uncommon and usually very curable.

The Procedure

Now that you've learned about thyroid nodules, here is information about the procedure:

The thyroid is an endocrine gland located in front of the trachea (windpipe) at the top of the neck. In fine needle aspiration, a needle is inserted into the thyroid to obtain a sample of thyroid cells.

Alternative Names: Biopsy – skinny-needle; Skinny-needle biopsyHanson Diabetes Center - Diagram of the Thyroid Gland

How the test is performed:

This test may be done in the health care provider’s office, radiology center or in a hospital. Usually anesthesia is not necessary because the needle is fine (very thin). You will lie on your back with a pillow under your shoulders and your neck extended.

The biopsy site is cleansed. The fine needle is then inserted into the thyroid, and a sample of thyroid cells and fluid is drawn into the needle. The needle is then withdrawn.

Pressure will be applied to the biopsy site to stop any bleeding, and the site will be covered with a bandage.

How to prepare for the test:

Inform the health care provider of any drug allergies you have, which medications you are taking, if you have bleeding problems, and if you are pregnant. You must sign a consent form.



How the test will feel:

The test will feel like a quick injection. You may feel a sting as the needle is inserted.



Why the test is performed:

This is a test to diagnose thyroid disease or thyroid cancer.



Normal Values:

A “normal” result means the thyroid tissue is normal in structure and the cells appear non-cancerous under a microscope.



What abnormal results mean:

Abnormal results may mean thyroid cancer, noncancerous tumors, or diffuse thyroid disease such as goiter or thyroiditis.




What the risks are:

The main risk is bleeding into or around the thyroid gland. If bleeding is severe, the trachea may be compressed. This complication is rare.




Special considerations:

Benign nodules should be re-evaluated periodically.